|Statement||edited by Arthur V. Everitt and John A. Burgess ; with a foreword by Fritz Verzár.|
|Contributions||Everitt, Arthur V., ed., Burgess, John A., ed.|
|LC Classifications||QP86 .H9|
|The Physical Object|
|Pagination||xvii, 787 p. :|
|Number of Pages||787|
|LC Control Number||74020839|
Human aging is associated with increasing frailty and morbidity which can result in significant disability. Dysfunction of the hypothalamic‐pituitary‐adrenal (HPA) axis may contribute to aging‐related diseases like depression, cognitive deficits, and Alzheimer's disease in some older by: The hypothalamus is a structure of the diencephalon of the brain located anterior and inferior to the thalamus. It has both neural and endocrine functions, producing and secreting many hormones. In addition, the hypothalamus is anatomically and functionally related to the pituitary gland (or hypophysis Missing: aging book. Moreover, the endocrinological basis of aging in male and female organisms is very complex, with multiple hormones along the hypothalamic-pituitary (HP) axis interacting with each other via different feedback loops to maintain homeodynamic : Gurcharan Kaur, Jyoti Parkash. Notably, the hypothalamus is also a region where a majority of molecular pathways implicated in aging, such as nutrient sensing, inflammation, neural stem cell, proteostasis, and epigenetic.
The hypothalamic aging is critical for systemic aging. Functional changes in a group of the hypothalamic neurons contribute to age-associated decline in energy homeostasis, hormone balance, circadian rhythm, and by: 9. The Aging Hypothalamus: Gradual Loss of Homeostatic Regulation. The hypothalamus is a collection of distinct neurosecretory cells located at the base of the brain. These neurosecretory cells receive a multitude of external and internal signals from virtually all organs in the form of hypothalamus-end-organ by: The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and Cited by: The hypothalamus–pituitary complex is located in the diencephalon of the brain. The hypothalamus and the pituitary gland are connected by a structure called the infundibulum, which contains vasculature and nerve axons. The pituitary gland is divided into two Missing: aging book.
Adrenocorticotrophin (ACTH) is the anterior pituitary mediator of the hypothalamic–pituitary–adrenal axis that regulates responses to a variety of stressors, including hypoglycemia, psychological stressors such as fear, and physical stressors such as hypovolemia. The Pituitary, Fourth Edition, continues the tradition of a cogent blend of basic science and clinical medicine which has been the successful hallmark of prior editions. This comprehensive text is devoted to the pathogenesis, diagnosis, and treatment of pituitary disorders. The new edition has been extensively revised to reflect new knowledge derived from advances in molecular and cell biology. Oocyte attrition leading to loss of ovarian function has been viewed as the hallmark of reproductive aging leading to menopause; however, recent evidence suggests both hypothalamus and pituitary may play an active role in reproductive senescence. Yet, the mechanisms governing reproductive senescence are largely : Alexander Kucherov, Erkan Buyuk. The other two hormones that are released by the hypothalamus are oxytocin and antidiuretic hormone. These hormones are passed down the axons of nerves that travel between the hypothalamus and the posterior lobe of the pituitary gland. From the pituitary, they are released into the bloodstream to their target : Phed Students.