by U.S. Environmental Protection Agency, Environmental Research Laboratory in Athens, GA .
Written in English
|Other titles||Octanol, water partition coefficients for evaluation of hazardous waste land disposal, selected chemicals|
|Statement||J. Jackson Ellington and Frank E. Stancil, Jr|
|Contributions||Stancil, Frank E, Environmental Research Laboratory (Athens, Ga.)|
|The Physical Object|
|Pagination||3 p. ;|
The octanol/water partition coefficient is typically expressed in logarithmic form and is indicated as log K ow or log parameter is very common and it is obtained either using experimental procedures 14–16 or using estimation techniques, 17,18 or it is evaluated using computer programs based on models (e.g., MarvinSketch , ChemAxon Ltd., 19 Estimation Programs Interface (EPI. Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry, , pages, J. Sangster, , , John Wiley & Sons, Octanol/water partition coefficients for evaluation of hazardous waste land disposal selected chemicals, J. Jackson Ellington, Frank E. Stancil, Environmental Research Laboratory (Athens. Int. J. Mol. Sci. , 12 Keywords: quantitative structure-property relationship; n-octanol-water partition coefficient; semi-empirical electrotopological index 1. Introduction The logarithm of the molecular 1-octanol-water partition coefficient (log P) of compounds, which is a measure of hydrophobicity, is widely used in numerous Quantitative Structure-Activity Relationship. Knowledge of partition coefficient (log P) data can play a critical role in understanding the pharmacokinetic and pharmacodistributive properties of toxic organophosphorus (OP) a recently published gas chromatographic method, the octanol:water log P values for the compounds tabun (GA), sarin (GB), cyclosarin (GF), and O‐ethyl‐S‐(2‐diisopropylaminoethyl Cited by:
The Octanol‐Water Partition Coefficient. D. W. Connell. Faculty of Environmental Sciences, Griffith University, Nathan Campus, Kessels Road, Brisbane, Queensland, Australia Book Editor(s): Peter Calow DSc, PhD, CBiol, FIBiol Nature of the Octanolwater Partition Coefficient. Measurement of K OW Values Compound Types. The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-Octanol and Water. K ow is also frequently referred to by the symbol P, especially in the English literature.. K ow serves as a measure of the relationship between lipophilicity (fat solubility) and hydrophilicity (water solubility) of a substance. R. Bruggemann et al., Estimating Octanol / Water Partition Coefficients Croat. Chem. Acta 86 () states that if x y and y z, then x z. The relation is called a partial order and such a relation along with the set X is called a partially ordered set (poset), denoted (X,).As is . Octanol/water partition coefficient is very important index in Biological,toxicological and environmental area. The human body is made from water and lipids. If you know the distribution ratio of the chemicals to the octanol, you can estiamte bio accumulations. But this index is just ratio, and that is problem. / or / logP become.
Chao Liang, Jun-qin Qiao, Hong-zhen Lian, Determination of reversed-phase high performance liquid chromatography based octanol-water partition coefficients for neutral and ionizable compounds: Methodology evaluation, Journal of Chromatography A, /, , . Octanol‐water partition coefficients (log P) for simple organic compounds representing all principal classes have been retrieved from the literature. Available experimental details of measurement are documented from original articles. Pertinent thermodynamic relations are presented, with a discussion of direct and indirect methods of measurement. No physicochemical parameter in environmental toxicology and chemistry is better known than K OW, the octanol–water partition parameter, also called log P or log P oct, originates from research into quantitative structure–activity relationships (QSARs) first studies were from Corwin Hansch and were focused on optimizing the biological as well as the pharmacological. For example, SPARC computes the log of the octanol- water partition coefficient from activity coefficients in the octanol (y~) and water (y^) phases: 14 Fate Constants for Hazardous Waste Identification Rule (12) where M,, and Mw are solvent molecularities of octanol and water, respectively.